The Boston Red Sox and Detroit Tigers opened their three-game series Monday at Comerica Park in Detroit, with Detroit's Tarik Skubal scratched from the starting lineup and Tyler Holton named replacement starter [1].
Boston entered the game with a 13-21 record and had lost five of their last six games. Detroit held an 18-17 record and was riding a four-game winning streak over their last five outings [1].
The betting line favored Boston slightly at -110 moneyline odds over Detroit's -109, down from Detroit's initial status as a heavy favorite [1]. The over/under total was set at 8 runs.
A SportsLine simulation ran 10,000 iterations of the matchup, projecting the game would go over 8 combined runs with an expected total of about 9.3 runs scored [1].
The teams were scheduled to play the first game of the series on May 4, 2026, marking the start of the three-game set [1]. The series outcome will be decided over the next two days at Comerica Park.